Mast/stem cell growth factor receptor Kit (Protein name
), KIT_MOUSE from NCBI database.
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General Annotation
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Antigen Annotation
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Gene name:
Kit(Sl);
Protein name:
Mast/stem cell growth factor receptor Kit(SCFR);
Alternative:
Tyrosine-protein kinase Kit;Proto-oncogene c-Kit;
CD:
CD117;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Monomer in the absence of bound KITLG/SCF. Homodimer in the presence of bound KITLG/SCF, forming a heterotetramer with two KITLG/SCF molecules. Interacts (via phosphorylated tyrosine residues) with the adapter proteins GRB2 and GRB7 (via SH2 domain), and SH2B2/APS. Interacts (via C-terminus) with MPDZ (via the tenth PDZ domain). Interacts (via phosphorylated tyrosine residues) with the protein phosphatases PTPN6/SHP-1 (via SH2 domain), PTPN11/SHP-2 (via SH2 domain) and PTPRU (By similarity). Interacts with the protein kinase FES/FPS. Interacts with PLCG1. Interacts (via phosphorylated tyrosine residues) with PIK3R1.
Function:
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.
Subcellular Location:
Isoform 3
Cytoplasm
Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT GLU-207
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 3);TISSUE SPECIFICITY
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);MUTAGENESIS OF PHE-860
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
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Cited for: FUNCTION IN ACTIVATION OF PLCG1;INTERACTION WITH PLCG1;ALTERNATIVE SPLICING;PHOSPHORYLATION;GLYCOSYLATION;CHARACTERIZATION OF VARIANTS W37 LYS-586 AND W41 MET-835
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Cited for: INTERACTION WITH PIK3R1;FUNCTION IN PHOSPHORYLATION OF PIK3R1
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Cited for: UBIQUITINATION;SUBCELLULAR LOCATION;CATALYTIC ACTIVITY;PHOSPHORYLATION AT TYR-825;INTERACTION WITH PIK3R1;CHARACTERIZATION OF VARIANT W42 ASN-794;MUTAGENESIS OF TYR-723;TISSUE SPECIFICITY
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Cited for: ALTERNATIVE SPLICING;FUNCTION IN ACTIVATION OF PLCG1
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Cited for: INTERACTION WITH PTPN6/SHP-1 AND PTPN11/SHP-2;FUNCTION IN PHOSPHORYLATION OF PTPN6/SHP-1;MUTAGENESIS OF TYR-571 AND TYR-573
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Cited for: REVIEW ON ROLE IN SPERMATOGENESIS AND FERTILITY
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-571; TYR-573; TYR-706 AND TYR-938;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION IN MAST CELL MIGRATION;IN SIGNALING VIA FYN
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Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 25-314 IN COMPLEX WITH KITLG/SCF;DISULFIDE BONDS;GLYCOSYLATION AT ASN-296 AND ASN-303
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Cited for: VARIANTS W37 LYS-586; WV MET-664 AND W41 MET-835
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Vaild Sequence:
